DLOC Biosystems
Revolutionizing Drug Discovery
DLOC Biosystems
Developing the world's most advanced organ-on-chip technology that will make drug development faster, cheaper and safer.
The Problem We Aim To Solve
It takes on average $2.6B and 12 years to discover one successful drug because 90% drug candidates fail at the late and expensive clinical trial stages. The reason is that there are no accurate methods of drug performance prediction. Current methods used in the pre-clinical stage rely on tissue models that do not behave like in-vivo human tissues. Therefore, the reaction of these grown tissues to drugs is different from their reaction in the human body.
Problem Cause
Lab-grown tissues used in pre-clinical drug testing do not react to drugs as in the human body.
Cell behavior is strongly influenced by:
1) 3D tissue structure: Cell-cell interaction (cell polarity)
2) Tissue microenvironment: Cell-tissue interaction (ECM)
3) Organ systems: Organ-organ interaction (blood / Lymph)
All factors are lacking in current conventional solutions!
Our Revolutionary Organ-On-Chip Technology
Our product portfolio
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Duct Organ-On-Chip (DOOC)
A new revolutionary organ-on-chip
Porous ductal scaffold preserving the 3D structure and tissue microenvironment.
DLOC has developed and patented the most advanced organ-on-chip device on the market that allows for growing 3D human tissue in-vitro while preserving in-vivo tissue properties. DLOC has also developed and patented another automated device that operates multiple connected chips of different tissue types, to create a human-on-chip model. With DLOC’s technology, it is possible to test drugs on human models and accurately predict a drug’s success and failure prior to clinical trials. DLOC aims to offer pre-clinical trials on-chip testing service that would significantly reduce the cost of drug development and increase trial safety.
Human-On-Chip Operating System (HOS)
An automated machine that models the human body's circulatory, immune & hormonal systems across multi-organ models.
DLOC has developed and patented the Human-on-chip Operating System (HOS) to model the human body organ-organ interactions.
The device consists of two main components:
The Human-on-chip plate (HOC): this is a chip the size of the 12-well plate, which can connect multiple chips together in a system of multiplexed micro-valving & micro-channeling, creating a body-on-chip (BOC) model. The chip HOC is customizable to fit chips of various types creating a standardized model.
The Human-on-chip Operating System (HOS): this is a device that can control the fluid flow and measurements into the HOC. The HOS can sample and move very small volumes of fluid from different regions of the culture in and out of the system. In addition, it can measure in real-time tissue functionality using microscopy, spectroscopy, and FTIR.
AI-Powered Drug Testing (AI-HOS)
"Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less"
